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Colussi_Giacomo

Colussi Giacomo

Specializzazione Nefrologia

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FORMAZIONE

  • Laurea in Medicina e Chirurgia.
  • Specializzazione in Nefrologia Medica e in Urologia.

ESPERIENZA PROFESSIONALI

  • 2012-2017 Professore a Contratto, Università Bicocca di Milano (sede di Monza).
  • 2008-2017 Direttore U.O. Nefrologia, Dialisi e Trapianto Renale presso l’Ospedale Niguarda di Milano.
  • 2008-2012 Professore a Contratto, Università degli Studi di Milano.
  • 2002-2008 Direttore U.O. Nefrologia, Dialisi e Trapianto Renale presso l’Ospedale di Circolo Macchi di Varese.
  • 2002-2008 Professore a Contratto Università dell’Insubria di Varese.
  • 1976-2002 Specialista Nefrologo e Aiuto Ospedaliero, Divisione di Nefrologia, Dialisi e Trapianto Renale presso l’Ospedale Niguarda di Milano.

PUBBLICAZIONI SCIENTIFICHE 

Circa 400 pubblicazioni su riviste di specialità “peer.revied”, 4 monografie sulla calcolosi renale e disturbi del metabolismo degli elettroliti, 10 capitoli in libri di testo medici.

Tra le pubblicazioni più citate:

  • Imbasciati E., Surian M., Bottino S., Cosci P., Colussi G., Ambroso G.C., Massa E., Minetti L., Pardi G., Ponticelli C.: Lupus nephropathy and pregnancy.A study in 26 pregancies in patients with systemic lupus eritematosus and nephritis. Nephron 36, 46-51,1984.
  • Colussi G.: Prevenzione della nefrolitiasi. In "Attualità in Nefrologia:Contributo del Laboratorio", Atti del 3° Convegno di Formazione ed Aggiornamento Professionale, Pavia 7-8 Giugno 1985, Tipografia Viscontea, Pavia 1985, pg. 67-70.
  • Cinti S., Colussi G., Minola E., Dickersin G.R.: Parathyroid glands in primary hyperparathyroidism: an ultrastructural study of 50 cases. Hum. Pathol. 17, 1036-1046, 1986.
  • Colussi G., Rombolà G., De Ferrari M.E., Minetti L.: Hypouricemia due to increased tubular urate secretion . Nephron 48, 235-236, 1988.
  • Colussi G., Barbarano L., Airaghi C., Rolando P., Montoli A., Granata S., De Cataldo F., Minetti L.: Clinical spectrum of tubular disorders from light chains. In Minetti L., D'Amico G, Ponticelli C. eds, The Kidney in Plasma Cell Dyscrasias, Kluwer Academic Publishers, Dordrecht 1988, pg. 191-209.
  • Colussi G., Rombolà G., Surian M., De Ferrari M.E., Airaghi C., Benazzi E., Malberti F., Minetti L.: Effects of acute administration of acetazolamide and furosemide on lithium clearance in humans. Nephrol. Dial. Transplant. 4, 707-712, 1989.
  • Colussi G, Rombolà G., Surian M., De Ferrari M.E., Airaghi C., Benazzi E., Malberti F., Minetti L. Lithium clearance in humans: effect of acute administration of acetazolamide and furosemide. Kidney Int. 37 (Suppl 28), S63-S66, 1990.
  • Colussi G, Rombolà G, Verde G, Airaghi C, Loli P, Minetti L. Distal nephron function in Bartter’ s syndrome: abnormal conductance to chloride in the cortical collecting tubule? Am J Nephrol 1992; 12: 229-239.
  • Montoli A, Colussi G, Minetti L. Hypercalcemia in Addison’s disease; calciotropic hormone profile and bone histology. J Int Med 1992; 232: 535-540.
  • Colussi G, Rombolà G, De Ferrari ME. Distal Nephron function in familial hypokalemia-hypomagnesemia (Gitelman’s syndrome). Nephron 1994; 66: 122-123.
  • Colussi G, Rombolà G, De Ferrari ME, Macaluso M, Minetti L. Correction of hypokelemia with antialdosterone therapy in Gitelman’s syndrome. Am J Nephrol 1994; 14: 127-135.
  • Rombolà G, Colussi G, Guastoni C, Civati G, Minetti L. Lymphocytic intracellular pH and Na/H exchanger activity in hemodialysis patients. Am J Nephrol 1995; 15: 24-30.
  • Colussi G, Macaluso M, Brunati C, Minetti L. Calcium metabolism and calciotropic hormone levels in Gitelman’s syndrome. Min Electrolyte Metab 1994; 20: 294-301.
  • Guidi E, Colussi G, Rombolà G, Airaghi C, Minetti L, Malberti F. Evaluation of the tubuloglomerular feedback system in human subjects. Exp Nephrol 1995; 3: 61-64.
  • Colussi G, Cipriani D. Pseudohyperkalemia in extreme leukocytosis. Am J Nephrol 1995; 15: 450-452.
  • Colussi G, Rombolà G, Brunati C, De Ferrari ME. Abnormal reabsorption of Na/Cl by the thiazide-inhibitabble transporter of the distal convoluted tubule in Gitelman’s syndrome. Am J Nephrol 1997; 17: 103-111.
  • De Ferrari ME, Colussi G, Brunati C, Rombolà G, Civati G. Type IV renal tubular acidosis and uric acid nephrolithiasis in William’s syndrome. An unusual mode of renal involvement. Nephrol Dial Transplant 1997; 12: 1484-1486.
  • Mastroianni N, Bettinelli A, Bianchetti M, Colussi G, De Fusco M, Sereni F, Ballabio A, Casari G. Novel molecular variants of the Na-Cl cotransporter gene are responsible for Gitelman syndrome. Am J Hum Genet 1996; 59: 1019-1026.
  • Bettinelli A, Vezzoli G, Colussi G, Bianchetti MG, Sereni F, Casari G. Genotype-phenotype correlations in normotensive patients with primary renal tubular hypokalemic metabolic alkalosis. J Nephrol 1998; 11: 61-69.
  • Simon DB, Lu Y, Choate KA, Velasquez H, Al-Sabban E, Praga M, Casari G, Bettinelli A, Colussi G, Rodriguez-Soriano J, McCredie D, Milford D, Sanjad S, Lifton RP. Paracellin-1, a renal tight junction protein required for paracellular Mg2+ reabsorption. Science 1999; 285: 103-106.
  • Bettinelli A, Tosetto C, Colussi G, Tommasini G, Edefonti A, Bianchetti MG. Electrocardiogram with prolonged QT interval in Gitelman disease. Kidney Int 2002; 62: 580-584.
  • Montoli A, Colussi G, Massa O, Caccia R, Rizzoni G, Civati G, Barbetti F. Renal cysts and diabetes sindrome linked to mutations of the Hepatocyte Nuclear Factor-1b gene: decriptino of a new family with associated liver involvement. Am J Kidney Dis 2002; 40: 397-402.
  • Hu J, Mora S, Colussi G, Proverbio MC, Jones KA, Bolzoni L, De Ferrari ME, Civati G, Spiegel AM. Autosomal dominant hypocalcemia caused by a novel mutation in the loop 2 region of the human calcium sensing receptor extracellular domain. J Bone Miner Res 2002; 17: 1461-1469.
  • Colussi G. Cardiovascular genomics. Letter to the Editor. New Eng J Med 2003; 249: 1387-88.
  • Rampoldi L, Caridi G, Santon D, Boaretto F, Bernascone H, Lamorte G, Tardanico R, Dagnino M, Colussi G, Scolari F, Ghiggeri GM, Amoroso A, Casari G. Allelism of MCKD, FJHN and GCKD caused by impairment of uromodulin export dynamics. Hum Mol Genet 2003; 12: 3369-84.
  • Colussi G. Paricalcitol, Calcitriol, and Survival of Patients Undergoing Hemodialysis. Letter to the Editor. New Eng J Med 2003; 249: 1971.
  • Colussi G, Dossi F. Aldosterone and Potassium in dialysis patients. Nephrol Dial Transplant 2004; 19: 1938.
  • Colussi G. Pseudohyperkalemia in leukemias. Am J Kidney Dis 2006; 47: 373.
  • Imel EA, Peacock M, Pitukcheewannont P, Heller HJ, Ward LM, Shulman D, Kassem M, Rackoff P, Zimering M, Dalkin A, Drobny E, Colussi G, Shaker JL, Hoogendoorn EH, Hui SH, Econs MJ. Sensitività of Fibroblast Growth Factor 23 measurements in tumor-induced osteomalacia. J Clin Endocrinol Metab 2006; 91: 2055.
  • Colussi G, Frattini G. Quantitative analysis of convective dose in hemofiltration and hemodiafiltration: “Predilution” vs “postdilution” reinfusion. Hemodialysis Int 2007; 11: 76-85.
  • Colussi G,  Alberto Bettinelli, Silvana Tedeschi, Maria Elisabetta De Ferrari, Marie Louise Syrén, Nicolò Borsa, Camilla Mattiello, Giorgio Casari, Mario Giovanni Bianchetti. A thiazide test for the diagnosis of  tubular hypokalemic disorders. Clin J Am Soc Nephrol 2007; 2: 454-460.
  • Begström S, Patrosso MC, Colussi G, Salvadore M, Penco S, Lando G, Marocchi A, Ueda A, Nakamura M, Ando Y. A novel type of transthyretin amyloidosis, ATTR Asn124Ser, with co-localisation of k light chains. Amyloid 2007; 14: 141-145.
  • LynnM. Boyden, Murim Choi, Keith A. Choate, Carol J. Nelson-Williams, Anita Farhi, Hakan R. Toka, Irina R. Tikhonova,Robert Bjornson, Shrikant M. Mane, Giacomo Colussi, Marcel Lebel, Richard D. Gordon, Ben A. Semmekrot, Alain Poujol, Matti J. Valimaki, Maria E. De Ferrari, Sami A. Sanjad, Michael Gutkin, Fiona E. Karet, Joseph R. Tucci, Jim R. Stockigt,Kim M. Keppler-Noreuil, Craig C. Porter, Sudhir K. Anand, Margo L. Whiteford, Ira D. Davis, Stephanie B. Dewar, Alberto Bettinelli, Jeffrey J. Fadrowski, Craig W. Belsha, Tracy E. Hunley, Raoul D. Nelson, Howard Trachtman,Trevor R. P. Cole, Maury Pinsk, Detlef Bockenhauer, Mohan Shenoy, Priya Vaidyanathan, John W. Foreman, Majid Rasoulpour, Farook Thameem, Hania Z. Al-Shahrouri, Jai Radhakrishnan, Ali G. Gharavi, Beatrice Goilav, Richard P. Lifton.  Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities. Nature Genet 2012; 482: 98-102.
  • Colussi G, Ganon L, Penco S, Maria De Ferrari ME, Ravera F, Querques ML, Primignani P, Holtzman EJ, Dinour D. Chronic Hypercalcemia from Inactivating Mutations of Vitamin D 24-Hydroxylase (CYP24A1). Implications for Mineral Metabolism Changes in Chronic Renal Failure. Nephrol Dial Transplant 2014; 29: 636.
  • Colussi G, Vergara M, Wang Z, Roland R. Risk factors associated with efficacy outcomes in kidney transplantation: analysis of a contemporary cohort of patients from the A2309 trial. Clin Nephrol 2015; 83: 338.
  • Bertuzzi F, Marazzi M, De Carlis L, Rampoldi A, Bonomo M, Antonioli B, Tosca M, Galuzzi M, De Gasperi A, Colussi G. Sustained Islet Allograft Function After Peritransplant Treatment Using Exenatide With and Without Everolimus. Tranplantation 2016; 100: e117.
  • Casati C, Colombo VG, Perrino ML, Rossetti OM, Querques M, Giacomoni A, Binaggia A, Colussi G. Renal Transplants from Older Deceased Donors: Use of Preimplantation Biopsy and Differential Allocation to Dual or Single Kidney Transplant according to Histological Score Has No Advantages over Allocation to Single Kidney Transplant by Simple Clinical Indication. J Transplant 2018; Vol 2018: Article ID 4141756.
  • Colussi G, Casati C, Colombo VG, Camozzi MLP, Salerno FR. Renal transplants from older deceased donors: Is pre-implantation biopsy useful? A monocentric observational clinical study. World J Tranplant 2018; 8(4): 110-121.
  • Cherukuri S, Bajo M, Colussi G, Corciulo R, Fessi H, Ficheux M, Slon M, Weinhandl E, Borman N. Home hemodialysis treatment and outcomes: retrospective analysis of the Knowledge to Improve Home Dialysis Network in Europe (KIHDNEy) cohort. BMC Nephrology 2018; 19: 262.
  • Marks WH, Mamode N, Montgomery R, Stegall MD, Ratner LE, … Colussi G, et al. Safety and efficacy of eculizumab in the prevention of antibody‐mediated rejection in living‐donor kidney transplant recipients requiring desensitization therapy: A randomized trial. Am J Transplant 2019; 48(1):86-96.
  • Brunati MC, Gervasi F, Cabibbe M, Ravera F, Menegotto A, Querques M, Colussi G. Single session and weekly beta2-microglobulin removal with different dialytic procedures: comparison between high-flux standard bicarbonate hemodialysis, post-dilution hemodiafiltration, short frequent hemodialysis with the NxStage  technology and automated peritoneal dialysis.  Blood Purif 2019; 48(1): 86-96.
  • Lopez-Garcia SC, Emma F, Walsh SB, Fila M, Hooman N, Zaniew M, Bertholet-Thomas A, Colussi G, Burgmaier K, Levtchenko E, Sharma J, Singhal J, Soliman NA, Ariceta G, Basu B, Murer L, Tasic V, Tsygin A, Decramer S, Gil-Peña H, Koster-Kamphuis L, La Scola C, Gellermann J, Konrad M, Lilien M, Francisco T, Tramma D, Trnka P, Yüksel S, Caruso MR, Chromek M, Ekinci Z, Gambaro G, Kari JA, König J, Taroni F, Thumfart J, Trepiccione F, Winding L, Wühl E, Ağbaş A, Belkevich A, Vargas-Poussou R, Blanchard A, Conti G, Boyer O, Dursun I, Pınarbaşı AS, Melek E, Miglinas M, Novo R, Mallett A, Milosevic D, Szczepanska M, Wente S, Cheong HI, Sinha R, Gucev Z, Dufek S, Iancu D; European dRTA Consortium, Kleta R, Schaefer F, Bockenhauer D. Treatment and long-term outcome in primary distal renal tubular acidosis. Nephrol Dial Transplant. 2019 Jun 1;34(6):981-991.
  • Bertuzzi F, De Carlis L, Marazzi M, Rampoldi AG, Bonomo M, Antonioli B, Tosca MC, Galuzzi M, Lauterio A, Fava D, Dorighet P, De Gasperi A, Colussi G. Long-term Effect of Islet Transplantation on Glycemic Variability. Cell Transplant. 2018 May;27(5):840-846.
  • Colussi G, Brunati CCM, Gervasi F, Montoli A, Vergani D, Curci F, Minetti E (2020) A simple method for the calculation of dialysis Kt factor as a quantitative measure of removal efficiency of uremic retention solutes: Applicability to high-dialysate vs low-dialysate volume technologies. PLoS ONE (2020) 15(5): e0233331. https://doi.org/10.1371/journal.pone.0233331.
  • G. Colussi, A. Menegotto, M.L.Querques, F. Ravera, S. Verdesca, V. Colombo, E.E. Minetti. End-proximal tubule phosphate concentration increases as GFR falls in humans: measurement by means of a lithium clearance-based methodology. Nephol Dial Transplant. 2023;  38: 671–678.